Phil Foden (left) has played in one World Cup with Cole Palmer yet to feature at the tournament
Phil Foden. Cole Palmer are set to miss out when Thomas Tuchel names his 26-man England squad on Friday for this summer's World Cup.
Manchester United defender Harry Maguire will also be left out, with the 33-year-old saying he is "shocked. gutted" at the decision.
All three were named in Thomas Tuchel's previous squad in March for the friendlies against Japan and Uruguay.
However, Manchester City's Foden. Chelsea's Palmer - both attacking midfielders who can also play as forwards - have had inconsistent seasons for their respective clubs.
In a post on Instagram. Maguire confirmed: "I was confident I could have played a major part this summer for my country after the season I've had. I've been left shocked and gutted by the decision. I wish the players all the best."
Maguire's Manchester United team-mate Luke Shaw is also set to be omitted despite his impressive season.
Shaw was named inTuchel's 55-man provisional squadand there had been a clamour for his inclusion.
But, with Newcastle's Dan Burn. Manchester City's Nico O'Reilly in line to be called up, Shaw is expected to miss out.
Chelsea defender Levi Colwill. AC Milan defender Fikayo Tomori are expected to be left out, though Arsenal winger Noni Madueke is expected to make the cut - joining club-mates Bukayo Saka and Declan Rice.
The omissions of Maguire, Tomori. Colwill means Manchester City defender John Stones is set to be included, despite his injury-disrupted campaign.
Tuchel views Stones as a key player but has been concerned about the departing Manchester City man's fitness.
Crystal Palace midfielder Adam Wharton is another poised to miss out,. Manchester United midfielder Kobbie Mainoo is set to keep his place in the squad after earning a recall for the previous friendlies.
There is an expectation that Brentford midfielder Jordan Henderson, who has been a mainstay under Tuchel, will keep his place.
The World Cup, which takes place across the US, Mexico and Canada, starts on 11 June.
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Foden has played 49 times for England but started only 22 Premier League games for City this season, scoring seven goals. providing five assists across his 32 top-flight appearances.
Palmer has scored nine goals in 25 Premier League games during an injury-hit campaign for Chelsea. who are eighth in the Premier League after an inconsistent season.
Speaking to BBC Sport last month,Maguire, who has played 67 times for England. scored seven goals, said he was "desperate" to go to the World Cup.
"I think it would be my last World Cup for my country. I've been to two. I missed out on the Euros two years ago through injury, which just hurt a lot really. So I'm desperate to go, whatever role the manager would want me for," he said.
"Whether that's starting or whether it's deciding games late on. I still believe, even at my age, I'm arguably one of the best defenders in the world in both boxes. I don't think that's to question really."
England warm up for the tournament with friendlies against New Zealand and Costa Rica.
They then start their World Cup campaign against Croatia on 17 June, before further group games against Ghana and Panama.
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